Original air date: 10/05/2016 Runtime: 43:25 min. Willis must help a promising young soccer player make a life-altering decision after he's seriously injured when a bus carrying his entire team crashes, and another patient's hesitation to share that she's transgender makes it difficult for the doctors to diagnose her severe abdominal pain.
Original air date: 10/12/2016 Runtime: 42:29 min. Willis defies Campbell's orders when he helps Mario and Heather perform a radical procedure on a maintenance worker stuck under a boiler that exploded. Also, Angus' father, Dr. Desmond Leighton (Steven Culp), tries to seize Power of Attorney over Mike, who is still in a coma, even though Mike granted that right to his brother, Angus.
Original air date: 11/09/2016 Runtime: 42:47 min. Malaya must inform a college student who regains consciousness at Angels Memorial that she's the victim of a rape, and Willis and Campbell butt heads over a terminally ill woman who wants to end her life on her own terms. Annabeth Gish and Richard Lewis guest star.
Original air date: 11/30/2016 Runtime: 42:26 min. Willis, Leanne and Jesse risk their lives to operate on an officer with an explosive bullet lodged in her leg. Also, Mario, Noa and Guthrie treat a magician, Johnny Prentiss (Penn Jillette), who comes to Angels with trouble breathing.
Original air date: 12/07/2016 Runtime: 42:47 min. When a 13-year-old girl arrives at Angels Memorial following a seizure caused by spina bifida, the doctors are shocked to learn she is Campbell's daughter. Also, a workaholic deaf patient, Kathy Byrne (Marlee Matlin), and her translator arrive at Angels after their car rolls into the L.A. River.
Original air date: 12/21/2016 Runtime: 43:19 min. A code black at Angels Memorial takes a turn for the worse when a city-wide blackout leaves the hospital without power or back-up generators. As Campbell and Leanne divert high-risk patients to a nearby care center, Elliot and Heather are trapped in an elevator with a woman in labor, and Willis and Dr. Nolan (Kathleen Rose Perkins) try to help a 92-year-old woman who thinks it's 1942.
Original air date: 01/25/2017 Runtime: 43:23 min. After pulling a double shift, Mario risks his own life when he follows Willis to a construction site where two brothers are trapped on a crane 300 feet above the ground. Also, Leanne treats the wife of an orthopedist from Angels Memorial who is brought into the ER with mysterious injuries.
Original air date: 02/01/2017 Runtime: 42:43 min. The ER is quarantined when a viral outbreak jeopardizes the lives of the doctors and patients at Angels Memorial. Also, Ariel (Emily Alyn Lind), the young girl Leanne bonded with a year ago when she lost her father, returns to Angels.
Original air date: 02/08/2017 Runtime: 43:19 min. The doctors work with the Center for Disease Control and Prevention to find an antidote to the deadly viral outbreak at Angels Memorial. Also, Leanne makes a life-changing decision, and Jesse welcomes a new batch of residents, on the second season finale.