Original air date: 09/20/2010 Runtime: 41:41 min. In the aftermath of last season’s emotional finale in which House and Cuddy admitted they had feelings for each other, as Season Seven begins, they are exploring the ramifications of those feelings and attempting to make a real relationship work. Meanwhile, due to a colleague’s illness, Princeton Plainsboro is left without a neurosurgeon on site, threatening the hospital’s accreditation as a Level 1 Trauma Center. As the team attempts treatment to get their sick colleague back to work, they discover there is more to the illness than they originally suspected and turn to House for direction. Instead, House remains elusive, leaving the team on its own.
Original air date: 09/27/2010 Runtime: 43:57 min. When Della (guest star Alyson Stoner), a seemingly healthy and active 14-year-old, suddenly collapses during a skateboarding exhibition, House and his team struggle to diagnose her condition and reassure her parents who already have to cope with their son’s terminal illness. After her body rejects a donor lung, and with time running out to save her life, Della’s family is left with little hope of securing a new donor and faced with a seemingly impossible decision regarding the fate of both children. Meanwhile, House tries to appease an elderly father and his son at the clinic, and House and Cuddy begin to face the challenges of taking their romantic relationship into the workplace.
Original air date: 10/04/2010 Runtime: 43:46 min. When Alice (guest star Amy Irving), the author of a popular children’s book series, inexplicably suffers from a seizure moments before an attempt to take her own life, the Princeton Plainsboro team faces the challenges of evaluating both her underlying medical conditions, as well as her unstable psychological state. Unable to diagnose Alice, House becomes particularly motivated, as he’s a fan of her books, and is convinced that the key to unlocking the mysteries of Alice’s condition lies in the pages of her most recent novel. Meanwhile, House takes Cuddy on a double date with Wilson and his girlfriend, Sam (guest star Cynthia Watros), and makes a discovery that proves that life imitates art as the couple continues to make compromises in order to make their relationship work.
Original air date: 10/11/2010 Runtime: 43:42 min. When a patient named Margaret McPherson is admitted to Princeton Plainsboro after suffering severe and uncontrollable vomiting, House and the team make unexpected discoveries about her identity as they assess her symptoms. When the symptoms don’t improve, the team looks to the patient’s medical history to unearth more about her past. Meanwhile, House gives Chase’s new hire a cold welcome, and a visit from House’s massage therapist forces House and Cuddy to confront the reservations in their relationship.
Original air date: 10/18/2010 Runtime: 43:58 min. After a newborn experiences inexplicable breathing problems and liver failure, House and the team look at the baby’s mother, Abbey’s (guest star Jennifer Grey), own medical history for possible clues. When the team makes a discovery about her newborn’s health, Abbey is presented with a difficult decision that could potentially affect both her baby’s health and her own. Meanwhile, following Cuddy’s directive, House challenges Foreman and Taub to hire a female doctor to join the team. When Cuddy asks House to baby-sit her daughter, both House and Wilson learn a few hard lessons in parenting.
Original air date: 11/08/2010 Runtime: 43:57 min. It’s election season, and in the midst of a tight campaign, an incumbent New Jersey senator’s campaign manager falls ill with liver failure and temporary paralysis. Cuddy pushes House to add a female doctor to his team by hiring brilliant third-year medical student Martha Masters (guest star Amber Tamblyn) in Thirteen’s absence. House and the team are wary of the young doctor’s lack of experience and medical perspective, but are forced to give their new by-the-book teammate a chance to prove herself. After the campaigning senator makes a surprising announcement, House and the team look to the candidate to find clues about the patient’s condition. Meanwhile, Foreman learns that Taub has a past connection to Masters, and in an effort to save his patient’s life, House must make a critical decision that may compromise his relationship with Cuddy.
Original air date: 11/15/2010 Runtime: 43:56 min. After a 200-year-old medicine jar found on an off-shore shipwreck shatters in a teenage girl’s palm, she is admitted to Princeton Plainsboro for symptoms closely linked to smallpox. When the Center for Disease Control’s Dr. Dave Broda (guest star Dylan Baker) institutes a lockdown on the hospital and suspends House’s team’s ability to diagnose, Masters (guest star Amber Tamblyn) grows suspicious of Broda’s motives and becomes convinced that the patient is suffering from a different disease. The girl’s father soon experiences similar symptoms, and House is forced to make a precarious decision that puts his own life in jeopardy. Meanwhile, Wilson and Sam (guest star Cynthia Watros) comfort a 6-year-old chemotherapy patient who prompts them to examine their relationship.
Original air date: 11/22/2010 Runtime: 43:58 min. Science and faith are called into question when a patient is admitted to the hospital following his reenactment of the Crucifixion. The patient, Ramon Silva, refuses to undergo the prescribed treatment, and the team learns that after his daughter’s cancer was cured, he pledged an oath of self-sacrifice to God. With little time to save Ramon’s life, the team struggles to understand his reasoning and seemingly extreme religious convictions, but eventually learn that faith is not an argument. Meanwhile, Taub questions his wife Rachel about her relationship with an infidelity support group member and the team attends a co-worker’s wedding where Wilson’s relationship with Sam (guest star Watros) takes an unexpected turn.
Original air date: 01/17/2011 Runtime: 43:58 min. When a man (guest star Matthew Lillard) puts his life on the line to save a stranger who fell onto the subway tracks, he emerges from the dramatic scene miraculously unscathed but then suddenly collapses. Both the hospital and the town become captivated by the man’s selfless deed, but as the team works to diagnose his symptoms, they discover that the hero’s seemingly life-changing deed failed to break old habits. Meanwhile, House tries to avoid Cuddy’s birthday dinner with her opinionated mother Arlene (guest star Candice Bergen), and Taub draws unexpected attention when his face graces billboards advertising the hospital. As Taub and his wife reignite a physical relationship, Masters’ (guest star Amber Tamblyn) outside perspective helps him realize that it’s time to take action on his crumbling marriage.
Original air date: 01/24/2011 Runtime: 43:55 min. A teenage military trainee at a juvenile offender training camp suffers peculiar symptoms after enduring an intense training course, and mysteriously, his drill sergeant is soon admitted for similar symptoms. Unable to track down the cause of the shared illness, the team searches for clues in the trainee’s family medical history, and Masters (guest star Tamblyn) and House reveal a unique bond between the sergeant and trainee. Meanwhile, when an indecent photo of Chase is posted on a social-networking site following three different romantic encounters, Chase is determined to find out which girl is trying to publicly disgrace him. Also, sensing Cuddy’s stress over her daughter Rachel’s enrollment at a prestigious preschool, House secretly prepares Rachel for observations and reveals a soft spot for the toddler.
Original air date: 02/07/2011 Runtime: 43:58 min. Cuddy’s mother, Arlene (guest star Candice Bergen), is admitted to Princeton Plainsboro after complaining about unusual symptoms, but stubborn Arlene insists that House be removed from the case, forcing House to come up with non-conventional -- and illegal -- means to treat his patient. House instructs his team to follow his lead, and they discover details in Arlene’s personal life that she kept secret from Cuddy and her sister Lucinda (guest star Paula Marshall). Meanwhile, Taub’s ex-wife, Rachel, puts him in contact with her brother who hires Taub to work a job on the side in exchange for much-needed income, which winds up taking a physical and emotional toll on him. Later, Cuddy places her trust in House to ensure that her mother receives the proper medical treatment, leading "by the book" medical student Masters to reevaluate her responsibility to practice within a code of ethics and to follow her boss’ orders.
Original air date: 02/14/2011 Runtime: 43:57 min. When a waitress with a perfect memory suffers temporary paralysis, her older sister visits her in the hospital, which triggers high stress levels and even more health complications. The patient’s sharp memory proves detrimental when a grudge she’s been holding against her sibling gets in the way of receiving proper medical treatment, and Masters discovers that patching a broken sisterhood may prove to be more complex than diagnosing the patient. Meanwhile, Foreman volunteers to help Taub prepare for a medical examination, and House, determined to help Wilson get back in the dating scene, discovers Wilson’s secret new companion.
Original air date: 02/21/2011 Runtime: 43:52 min. House participates in a school’s Career Day and breaks a few rules by sharing explicit medical stories. Waiting outside the principal’s office, he meets two fifth-grade students (guest stars Austin Michael Coleman and Haley Pullos) who assess House’s relationship woes and try to help him understand how his selfish antics get in the way of showing Cuddy how he really feels.
Original air date: 02/28/2011 Runtime: 43:57 min. A patient is admitted after breaking out in a severe rash triggered by caustic chemical exposure at his blue-collar job. As the team treats him, they discover that he has led his wife to believe that he is still maintaining his once-lucrative real estate career. Meanwhile, Cuddy is honored with an award and needs House to be at the charity event for support, but his attendance is threatened when his patient’s battle to survive forces him to question his practice and his own happiness. Also, Chase and Masters teach each other a lesson in forging meaningful personal and professional relationships.
Original air date: 03/07/2011 Runtime: 43:56 min. Tension reaches new heights when Cuddy faces sobering news that propels her to reevaluate her priorities. While House is distracted by his concern for Cuddy’s well-being, the team treats a teenage patient whose worsening symptoms and suspicious body scars indicate more than just physical illness. Sensing the teen’s troubled emotional and mental state, Taub turns to the patient’s personal life for clues and uncovers disturbing home videos that could put the lives of his peers in danger. Meanwhile, Cuddy remains hopeful that House will be fully present when she needs him most, and a series of dreams, including a musical scene choreographed by Mia Michaels, provide glimpses into her life and her relationship with House.
Original air date: 03/14/2011 Runtime: 43:53 min. A young professional champion bullfighter is admitted for treatment after being attacked by a bull. After conducting multiple inconclusive tests, the team enlists House’s advice outside of the hospital while he attends to a few issues away from the case. Back in the hospital, the bullfighter’s condition continues to worsen, but with disappearing symptoms and the patient’s more frequent mini-seizures, the team’s last option is risky open-heart surgery. Meanwhile, Masters develops a crush on their bullfighter patient much to Taub’s surprise.
Original air date: 03/21/2011 Runtime: 43:47 min. A young homeless man who is a former drug addict is found in a park showing signs of olfactory impairment and horrific scars and burn marks on his chest. With an uncertain identity and the patient’s severely worsening conditions, the team looks to the patient’s personal records and family history in order to understand his detachment. Meanwhile, Cuddy confides in Wilson and expresses her guilt for ending her relationship with House, and just as the team warms up to the patient, they discover a disturbing secret about the man whose life they saved.
Original air date: 04/11/2011 Runtime: 43:56 min. Thirteen has been in prison for the past six months, but the real mystery for House is what she did to get there. When she exits the prison, Thirteen is surprised to find him waiting for her, and unaware of his plans for the two of them for the next few days. As House probes Thirteen for more information, intent on solving the puzzle of her disappearance and mysterious incarceration, they travel to an annual spud-gun competition. The two join forces to compete against House’s much younger, overconfident rival, and along the journey uncover secrets and truths about each other. Meanwhile, at the hospital, the team treats a science teacher suffering from severe respiratory illness, and when the team inspects the patient’s house for clues, they learn he’s a hoarder. But upon a second visit to the house, they uncover something shocking among the many piles. Also, Taub tries to get back into the dating scene.
Original air date: 04/18/2011 Runtime: 43:48 min. Masters faces a career crossroads on her last day as a medical student and struggles with the choice to continue on the path to become a surgeon or to accept the rare opportunity to join House’s team officially. Meanwhile, the team treats a 16-year-old girl who inexplicably collapsed days before embarking on an ambitious sailing tour around the globe. Despite the patient's life-changing diagnosis, the patient's family insists on getting her back on the seas in time for her potentially record-breaking launch. But to the team's surprise, including House, Masters makes a bold decision regarding the patient’s treatment.
Original air date: 05/02/2011 Runtime: 43:57 min. After suffering partial paralysis while searching for a long-lost love, lottery winner Cyrus Harry (guest star Donal Logue) is brought to Princeton Plainsboro for treatment by House and the team. Cuddy’s mother (guest star Bergen) threatens to sue the hospital for malpractice, jeopardizing both Cuddy and House’s medical licenses. Chase and Foreman make a bet that tests each one in different ways.
Original air date: 05/09/2011 Runtime: 43:57 min. When House and Wilson bet on a boxing match and disagree over the outcome, Wilson gives him exactly one day to pay up or prove him wrong. House presses the boxer for more information to help prove his case and ends up attempting to breathe new life into the losing fighter’s career. Meanwhile, the team begins to suspect House may have another type of drug problem.
Original air date: 05/16/2011 Runtime: 43:57 min. Thirteen’s ex-con friend, Darrien (guest star Amy Landecker), arrives at Thirteen’s apartment unannounced and in need of urgent medical attention. When she finds out that her friend has relapsed into drug use, Thirteen promises not to take her to the hospital where the cops could find her and instead turns to Chase in desperation. Meanwhile, House deals with devastating information, and Taub begins to come to terms with surprising news.
Original air date: 05/23/2011 Runtime: 43:58 min. In the season finale well-known performance artist Afsoun Hamidi (guest star Aghdashloo) is admitted to the hospital, but when the team learns that her symptoms may have been self-inflicted as part of a documentary for her latest performance piece, they begin to question whether treatments are necessary and if they are unwittingly participating in the creation of a piece of her art. Meanwhile, a situation prompts House to do something that could change his relationship with Cuddy and Wilson permanently.