Original air date: 09/24/2010 Runtime: 42:16 min. In the sixth season premiere, it's a year after Sam and Dean faced the Apocalypse. Dean has given up hunting and is living with Lisa (guest star CINDY SAMPSON) and her son Ben (guest star NICHOLAS ELIA). Mysteriously freed from his cage in hell, Sam finds Dean and tells him he needs to rejoin the fight and introduces Dean to a world and a family he never even knew existed: the Campbells, his mother's family, lead by none other than their Grandfather Samuel (guest star MITCH PILEGGI).
Original air date: 10/01/2010 Runtime: 41:20 min. Sam investigates a case about missing babies whose parents are being murdered. At one of the crime scenes, he discovers a baby that was left behind and calls Dean for help. Reluctant to leave Lisa and Ben, Dean finally agrees to meet Sam and surprises his brother with how parental he has become. The brothers take the baby to Samuel, who decides to raise it as a hunter, which infuriates Dean. However, before they can decide the baby's future, a shapeshifter breaks in and attempts to kidnap the baby.
Original air date: 10/08/2010 Runtime: 41:07 min. Sam and Dean call Castiel (series star MISHA COLLINS) for help when they investigate a case about several dead police officers who seem to have been killed by the plagues of Egypt. Castiel confirms the staff of Moses was used to kill the cops and tells Sam and Dean that Heaven is in a state of chaos and God's weapons have been stolen. The three head off to find the thief and come face to face with an old enemy.
Original air date: 10/15/2010 Runtime: 40:22 min. After Bobby (recurring guest star JIM BEAVER) discovers Crowley (guest star MARK SHEPPARD) has no intentions of returning Bobby's soul, The hunter takes matters into his own hands. He calls on Sam and Dean for help after he unearths one of Crowley's deepest secrets. Meanwhile, Sam and Dean learn what Bobby does all day when they are not around. Series star Jensen Ackles makes his directorial debut.
Original air date: 10/22/2010 Runtime: 41:50 min. After a group of young girls go missing, Sam and Dean realize that a group of vampires have taken up residence in the small town. After a fight with two of the blood-suckers, Dean is bitten and turns into a vampire. Samuel tells Dean he can change him back but hed have to get the blood of the vampire who turned him. Dean infiltrates the nest and runs into the Alpha.
Original air date: 10/29/2010 Runtime: 40:25 min. The truth hurts! Sam and Dean investigate a series of suicides and discover the victims were being told brutal truths that drove them crazy. They find out someone is invoking Veritas, The Goddess of Truth, forcing people to be cruelly honest against their will and Dean is the next victim. Dean is forced to tell Sam the truth about how he feels about his return from Hell.
Original air date: 11/05/2010 Runtime: 41:09 min. Does Samuel have a secret? Dean becomes suspicious of Samuel's motives but Sam isn't sold on the idea that their grandfather is doing anything wrong. The brothers go along on a hunt with Samuel and the other Campbells, but things go terribly awry.
Original air date: 11/12/2010 Runtime: 41:51 min. Dean and Sam investigate what seems to be a werewolf killing but turns out to be a skinwalker (guest star ANDREW ROTHENBERG) posing as a family dog who is taking revenge on his owner's enemies. After capturing the dog, he turns human and tells Sam and Dean that an Alpha skinwalker has created many sleeper cells that will rise on his command and kill their families. The only way to stop the mass murders is to find and kill the Alpha.
Original air date: 11/19/2010 Runtime: 42:06 min. While Sam and Dean are investigating a UFO sighting, Dean is abducted from a crop circle. However, when he awakens, he discovers he isn't dealing with aliens, but fairies! Unfortunately, only Dean can see the fairy that keeps attacking him which makes tracing and stopping them difficult. The brothers become even more perplexed when Sam's investigation leads them to a world full of elves, gnomes and a leprechaun.
Original air date: 12/03/2010 Runtime: 41:57 min. The demon Meg (guest star RACHEL MINER) kidnaps Sam and Dean and tries to force them to tell her where Crowley (guest star MARK A. SHEPPARD) is hiding. Sam makes her a deal they will help her find Crowley if she promises to torture him for information about how to get Sam's soul back. Castiel joins the fight but finds it difficult to work with Meg.
Original air date: 12/10/2010 Runtime: 41:33 min. Dean seeks out Death (guest star JULIAN RICHINGS) to help get Sam's soul back. Death tells Dean he will help Sam if Dean will agree to act as Death for 24 hours. Meanwhile, Sam decides he doesn't want his soul back and asks Balthazar (guest star SEBASTIAN ROCH for a protective spell to keep his soul out of his body. Balthazar tells Sam he needs the blood of his father for the spell to work and since John Winchester is dead, Sam decides Bobby is the next best thing.
Original air date: 02/04/2011 Runtime: 41:56 min. Death returns for a meeting with Dean! Dean and Bobby anxiously wait for Sam to wake up to see if Death was able to restore his soul without causing Sam to lose his mind. Meanwhile, Dean and Bobby investigate a disappearance of virgins and discover dragons are behind the kidnappings. Bobby sends Dean to a doctor who owns the only weapon in the world that can slay a dragon, but Dean must prove himself worthy enough to take it.
Original air date: 02/11/2011 Runtime: 40:42 min. Sam starts to have flashbacks to a case he worked on with Samuel before he reconnected with Dean. When Sam receives a mysterious text with coordinates to a small town, The brothers decide to investigate and Dean is surprised when the townspeople start telling him some of the things Sam did while he lived there.
Original air date: 02/18/2011 Runtime: 40:08 min. Ben (guest star NICOLAS ELIA) calls Dean and tells him Lisa (guest star CINDY SAMPSON) is in trouble. Dean leaves Sam to investigate a case alone and rushes home to rescue Lisa, however, he's not prepared for what meets him at the door. Meanwhile, Sam discovers the men that were murdered were all a part of a cruel practical joke played on a female co-worker who went missing.
Original air date: 02/25/2011 Runtime: 42:08 min. Raphael (guest star LANETTE WARE) launches an attack on Castiel and his allies, sending a particularly frightening angelic hitman (guest star CARLOS SANZ) after Balthazar, Sam and Dean. In an effort to protect the brothers, Balthazar sends them to an alternate universe where they are the stars of a TV show called Supernatural and they are actors named Jensen Ackles and Jared Padalecki. The brothers are confused when Castiel appears to be a tweet-happy actor named Misha Collins and Sam is married to Ruby (guest star GENEVIEVE CORTESE).
Original air date: 03/04/2011 Runtime: 42:17 min. Sam, Dean and Bobby set out in search of The Mother of All's (guest star JULIA MAXWELL) latest monster. While investigating, They run into Samuel and Gwen Campbell (guest star JESSICA HEAFEY), who are also hunting the creature. Samuel and Bobby get into a heated fight about how to handle the case.
Original air date: 04/15/2011 Runtime: 41:26 min. After Balthazar changes history and keeps the Titanic from sinking, Fate (guest star KATIE WALDER) intervenes and begins killing those that would have died on the ship. Castiel tells Sam and Dean that Fate is very upset with the two of them and the only way they can stay alive is to kill her.
Original air date: 04/22/2011 Runtime: 41:06 min. While searching for a way to defeat Eve, Dean stumbles upon the journal of Samuel Colt (guest star SAM HENNINGS) journal in the Campbell library. Realizing Samuel might have the answer to their problems, Sam and Dean ask Castiel to send them back in time so they can meet the man himself. While Sam is a bit reluctant to time travel, Dean is beside himself with excitement to return to the Wild, Wild West.
Original air date: 04/29/2011 Runtime: 41:32 min. Sam, Dean, Bobby and Castiel track Eve (guest star JULIA MAXWELL) to a small town in Oregon. The guys discover the townspeople have been converted to demons, but surprisingly, They all appear to be dying. When they finally do meet Eve, she decides to torture the brothers by bringing back their mother, Mary Winchester (guest star SAMANTHA SMITH), as a demon.
Original air date: 05/06/2011 Runtime: 41:37 min. In this episode written and directed by executive producer Ben Edlund, Castiel tells Sam, Dean and Bobby about the war in Heaven and how he and Raphael (guest star DEMORE BARNES) became enemies. Bobby believes Castiel is hiding something, but Dean refuses to believe it.
Original air date: 05/20/2011 Runtime: 42:16 min. In the sixth season finale, The wall comes down in Sam's mind and all hell breaks loose. Dean and Bobby are, for once, at a total loss on how to help him and are forced to stand by and do nothing while Sam breaks. The battle for heaven comes to a head in this episode written by series creator Eric Kripke.